The project develops advanced methodologies and data resources for genome-wide modeling of proteins, protein interactions, and assessment of phenotypic effects of genetic mutations.

Sponsored by

National Science Foundation

Biotechnology and Biological Sciences Research Council

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Database Status

 

Type of GWYRE Entry Coordinates of chain 1 Coordinates of chain 2 Structure of GWYRE entry Number of GWYRE entries
Experimental PDB PDB   PDB 2,797
PDB + PDB PDB PDB   Predicted by GRAMM 859
Model + PDB Model PDB   Predicted by GRAMM 583
Model + Model Model Model   Predicted by GRAMM 1,925

Related Resources

 

GWIDD

GWIDD is an integrated resource for structural studies of protein-protein interactions on genome-wide scale

Phyre

Phyre is a web portal for protein modeling, prediction and analysis

GRAMM

Protein-Protein Docking server

PhyreRisk

PhyreRisk is a dynamic web application developed to enable the exploration and mapping of genetic variants onto experimental and predicted sturctures of proteins and protein complexes

Missense3D

Missense3D predicts the structural changes introduced by an amino acid substitution and is applicable to analyse both PDB coordinates and homology-predicted structures.

Dockground

Benchmarks, Decoys, Templates, and other knowledge resources for Docking.

GWYRE should be cited as:

Malladi, S., Powell, H.R., David, A., Islam, S.A., Copeland, M.M., Kundrotas, P.J., Sternberg, M.J.E., Vakser, I.A. GWYRE: A Resource for Mapping Variants onto Experimental and Modeled Structures of Human Protein Complexes, J. Mol. Biol., 2022, 434:167608.

Contact us

Center for Computational Biology
University of Kansas, Lawrence, KS 66045, USA.

vakser@ku.edu

Centre for Integrative Systems Biology and Bioinformatics (CISBIO)
Imperial College London, London. SW7 2AZ, UK.

m.sternberg@imperial.ac.uk