The project develops advanced methodologies and data resources for genome-wide modeling of proteins, protein interactions, and assessment of phenotypic effects of genetic mutations.


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Database Status


Type of GWYRE Entry Coordinates of chain 1 Coordinates of chain 2 Structure of GWYRE entry Number of GWYRE entries
ExperimentalPDB PDB   PDB 2,797
PDB + PDBPDB PDB   Predicted by GRAMM859
Model + PDB Model PDB   Predicted by GRAMM583
Model + Model Model Model   Predicted by GRAMM1,925

GWYRE should be cited as:

Malladi, S., Powell, H.R., David, A., Islam, S.A., Copeland, M.M., Kundrotas, P.J., Sternberg, M.J.E., Vakser, I.A., 2022, GWYRE: A resource for mapping variants onto experimental and modeled structures of human protein complexes, J. Mol. Biol., doi:10.1016/j.jmb.2022.167608.

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Center for Computational Biology
University of Kansas, Lawrence, KS 66045, USA.

Centre for Integrative Systems Biology and Bioinformatics (CISBIO)
Imperial College London, London. SW7 2AZ, UK.